Every ending runs through one rooftop

1. Keep Takemura alive in Search and Destroy — only the achievement needs it.
2. On the rooftop, call Hanako.
3. Take the blockers Misty and Vik offer.
4. Finish Where is My Mind? on the orbital station.
5. Sign Arasaka’s contract to become an engram, or refuse and go back to Earth with months to live.

Quests on the wayLast CaressTotalimmortalWhere is My Mind?

• Without Takemura there is no Arasaka support and Oda does not appear; Anders Hellman makes the offer in orbit instead, and the achievement does not unlock.
• Going back to Earth is the ending where a relationship with River or Kerry continues.

1. Finish Panam’s side job Queen of the Highway.
2. On the rooftop, call Panam.
3. Take the blockers.
4. In Mikoshi, let the body go back to V.
5. Finish All Along the Watchtower.

Quests on the wayWe Gotta Live TogetherForward to DeathBelly of the BeastChangesAll Along the Watchtower

• The ending that continues a relationship with Panam or Judy, who leave Night City whatever you choose.

1. Finish Rogue’s Blistering Love — or give Johnny his second chance at the end of Chippin’ In for the secret route.
2. On the rooftop, follow Johnny’s plan to Rogue — or wait about five minutes for his own plan.
3. Take the pseudoendotrizine: Johnny drives the assault.
4. In Mikoshi, let the body go back to V.
5. Finish Path of Glory.

Quests on the wayFor Whom the Bell TollsKnockin’ on Heaven’s DoorChangesPath of Glory

• After the secret route Rogue is still alive in the epilogue — the only way she appears in Path of Glory.
• The ending that continues a relationship with River or Kerry.

1. Open Panam’s or Rogue’s route, or the secret one.
2. On the rooftop, take that route.
3. In Mikoshi, let Johnny keep the body; V goes beyond the Blackwall with Alt.
4. Finish New Dawn Fades.

Quests on the wayChangesNew Dawn Fades

• Johnny walks out of Night City in V’s body. Every relationship V had ends here.

1. In Phantom Liberty, end with King of Swords (give So Mi to Reed) or King of Pentacles (side with Reed and refuse Songbird).
2. Accept Reed’s offer when he makes it.
3. Call Reed — in Who Wants To Live Forever or on the rooftop in Nocturne Op55N1.
4. Finish Things Done Changed.

Quests on the wayWho Wants To Live ForeverThings Done Changed

• The epilogue changes with the Firestarter path: if the NCX spaceport was attacked, tensions two years on point towards another corporate war.
• A reunion with Kerry some time afterwards is the one relationship this ending can keep.

1. On the rooftop, pick the first option and tell Johnny you could put all this to rest.
2. Toss the pills.

• No achievement. The game treats it as V’s death and reloads your last save before the rooftop.